Greg A. Kirchenbaum, Ph.D.
Director of Basic B cell Research
Personal Statement
I have a long-standing fascination with the immune system, and specifically the development and maintenance of immunology memory in the context of natural infection or prophylactic vaccination. Since joining CTL, I have been exploring the utility of the ImmunoSpot (ELISPOT/FluoroSpot) assay platform for performing detailed characterization of rare antigen-specific B cell populations.
Education and Training
- BS with Honors, (2006), Biology, Florida State University
- PhD, 2013, Immunology, University of Colorado, Denver
- Post-doctoral Fellowship, Vaccine and Gene Therapy Institute of Florida
- Post-doctoral Fellowship, Center for Vaccines and Immunology, University of Georgia
Recent Publications
- Wolf, C.; Köppert, S.; Becza, N.; Kuerten, S.; Kirchenbaum, G.A.; Lehmann, P.V. Antibody levels poorly reflect on the frequency of memory B cells generated following SARS-CoV-2, seasonal influenza, or EBV infection. Cells 2022, 11, 3662.
- Köppert S, Wolf C, Becza N, Sautto GA, Franke F, Kuerten S, Ross TM, Lehmann PV, Kirchenbaum GA. Affinity tag coating enables reliable detection of antigen-specific B cells in ImmunoSpot assays. 2021. Cells. Jul 17;10(8):1843.
- Lehmann AA, Kirchenbaum GA, Zhang T, Reche PA, Lehmann PV. Deconvoluting the T cell response to SARS-CoV-2: specificity versus chance and cognate cross-reactivity. 2021. Front Immunol. May 28; 12:635942.
- Przybyla A. Lehmann AA, Zhang T, Mackiewicz J, Galus L, Kirchenbaum GA, Mackiewicz A, Lehmann PV. Functional T cell reactivity to melanocyte antigens is lost during the progression of malignant melanoma, but is restored by immunization. 2021. Cancers. Jan 9;13(2):233.
- Franke F, Kirchenbaum GA, Kuerten S, Lehmann PV. IL-21 in conjunction with anti-CD40 and IL-4 constitutes a potent polyclonal B cell stimulator for monitoring antigen-specific memory B cells. 2020. Cells. Feb 13;9(2):433.
- Lehmann PV, Suwansaard M, Zhang T, Roen DR, Kirchenbaum GA, Karulin AY, Lehmann A, Reche PA. Comprehensive evaluation of the expressed CD8+ T cell epitope space using high-throughput epitope mapping. 2019. Front Immunol. Apr 26;10:655.