Greg A. Kirchenbaum, Ph.D.

Director of Basic B cell Research

Personal Statement

I have a long-standing fascination with the immune system, and specifically the development and maintenance of immunology memory in the context of natural infection or prophylactic vaccination. Since joining CTL, I have been exploring the utility of the ImmunoSpot (ELISPOT/FluoroSpot) assay platform for performing detailed characterization of rare antigen-specific B cell populations.

Education and Training
  • BS with Honors, (2006), Biology, Florida State University
  • PhD, 2013, Immunology, University of Colorado, Denver
  • Post-doctoral Fellowship, Vaccine and Gene Therapy Institute of Florida
  • Post-doctoral Fellowship, Center for Vaccines and Immunology, University of Georgia
Recent Publications
  1. Wolf, C.; Köppert, S.; Becza, N.; Kuerten, S.; Kirchenbaum, G.A.; Lehmann, P.V. Antibody levels poorly reflect on the frequency of memory B cells generated following SARS-CoV-2, seasonal influenza, or EBV infection. Cells 2022, 11, 3662.
  2. Köppert S, Wolf C, Becza N, Sautto GA, Franke F, Kuerten S, Ross TM, Lehmann PV, Kirchenbaum GA. Affinity tag coating enables reliable detection of antigen-specific B cells in ImmunoSpot assays. 2021. Cells. Jul 17;10(8):1843.
  3. Lehmann AA, Kirchenbaum GA, Zhang T, Reche PA, Lehmann PV. Deconvoluting the T cell response to SARS-CoV-2: specificity versus chance and cognate cross-reactivity. 2021. Front Immunol. May 28; 12:635942.
  4. Przybyla A. Lehmann AA, Zhang T, Mackiewicz J, Galus L, Kirchenbaum GA, Mackiewicz A, Lehmann PV. Functional T cell reactivity to melanocyte antigens is lost during the progression of malignant melanoma, but is restored by immunization. 2021. Cancers. Jan 9;13(2):233.
  5. Franke F, Kirchenbaum GA, Kuerten S, Lehmann PV. IL-21 in conjunction with anti-CD40 and IL-4 constitutes a potent polyclonal B cell stimulator for monitoring antigen-specific memory B cells. 2020. Cells. Feb 13;9(2):433.
  6. Lehmann PV, Suwansaard M, Zhang T, Roen DR, Kirchenbaum GA, Karulin AY, Lehmann A, Reche PA. Comprehensive evaluation of the expressed CD8+ T cell epitope space using high-throughput epitope mapping. 2019. Front Immunol. Apr 26;10:655.

Greg Kirchenbaum’s Publications