Neutralizing Antibody (NAb) assays
Accelerate Your Immune Monitoring Studies with Contract Laboratory Services
Neutralizing antibody (NAb) activity plays an important role the immune system's response to viral infections, vaccines, and immuno-therapeutics. NAb assays can be of particular importance in evaluating immunogenicity in preclinical and clinical studies (phase I, II, and III).
NAb are key indicators of host control of pathogens and immune responses generated by vaccines and immuno-therapeutics. As an example, our CRO immunoassay services include reliable readouts of NAb specific to SARS-CoV-2 and various other pathogens and gene therapy vectors (e.g., AAV).
Alternatively, NAb can bind to biotherapeutic drug products and prevent them from performing their intended biological function. Monitoring such antibodies are of key importance in immunotherapeutic modalities that have the potential to induce such outcomes.
As pioneers in immune monitoring, our Contract Laboratory Services team has decades of proven expertise in performing NAb microneutralization services, and we have established and validated various assays for our pharmaceutical and biotech Clients. Reach out to our experienced NAb immune assay team today for customized services to help support your projects.
*Representative microneutralization assay
Neutralization Assays Provide High-Throughput Readouts
Our highly trained NAb assay team utilizes microneutralization assays with relevant cell lines and labeled pseudoviruses and other antigens. Such assays are performed in our regulated biosafety level 2 (BSL2) laboratories using ImmunoSpot® analyzers and software, which are robot-compatible for high-throughput, automated assays.
For more than 20 years, some of the world's top pharmaceutical Clients have trusted us with their extensive immune monitoring needs.
