T Cell ELISPOT Testing
Let Our CRO Team Fast-Track Your T Cell ELISPOT
As pioneers in the ELISPOT arena, the Contract Research Laboratory Services team has more than a decade of proven expertise in the field of T cell ELISPOT.
Our CRO has developed and validated various customized T cell ELISPOT assays for pharmaceutical and biotechnology clients—large and small—spanning diverse antigenic systems. We have successfully deployed and optimized high-throughput assays for key clinical trials (Phase I, II, and III) and testing for translational and preclinical studies.
Let us help you get your project on the right footing. Reach out to our experienced immune monitoring team today!
Single, double, and multi-color T cell ELISPOT and FluoroSpot images
Our T cell ELISPOT assays can utilize either fresh or cryopreserved PBMC
Optimized ELISPOT/FluoroSpot assays can reliably detect antigen-specific T cells even if they occur in frequencies of 0.0001% within PBMC which is a single analyte-secreting T cell within a million bystander cells.
These immune assays range from single color ELISPOTs to novel, high-throughput multiplexed FluoroSpot assays that can be tailored to fit your specific project needs. Beyond clinical studies for the human system, our contract laboratory services have developed T cell ELISPOT assays for other species including non-human primates (NHP), rat, murine, and porcine systems, just to name a few.
We offer a wide range of single and multi-color T cell ELISPOT and FluoroSpot services to assess immunogenicity in test subjects. Our CRO offers both ready-to-go, CTL kit-based T cell ELISPOT assay services or from others as well as custom-designed assays to fit our Clients' specific project needs.
Our highly trained immune monitoring experts can help coordinate multiple clinical sites and can walk clients through the complex aspects of T cell ELISPOT assay development, validation, deployment, and study logistics. Reach out to us to discuss your specific T cell ELISPOT project needs.
Our T cell ELISPOT/ImmunoSpot® method allows for complete characterization of immunogenicity:
- Testing T cell-mediated immunity for pre-clinical and clinical specimens
- High-throughput assay testing capabilities
- Epitope mapping with overlapping peptides
- Measurement of CD4+ and CD8+ T cell responses
Based on the assay configuration, CD4+ and CD8+ subsets and associated effector and memory populations can be assessed.
To further explore our extensive T cell assay services and related products, please refer to our T cell ImmunoSpot® kits and our CRO brochure.
As a key mission, the CRO specializes in developing and validating custom immune assays that are tailored to fit our clients’ specific project needs.
Many such optimized assay services have helped our Pharma and Biotech clients evaluate T cell immunogenicity in preclinical studies and clinical trials:
- Immunotherapeutics (e.g., oncology, autoimmunity)
- Vaccine studies (e.g., infectious diseases, cancer vaccines)
- Transplantation (e.g., allo, MLR)
- Gene therapies (e.g., AAV-9)
Safety assessments (e.g., ADA)
