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Hricik DE, Rodriguez V, Riley J, Bryan K, Tary-Lehmann M, Greenspan N, Dejelo C, Schulak JA, Heeger PS.

Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients.
American Journal of Transplantation. 2003, 3, 878-884.

Transplantation Immunology -

Anthony DD, Lehmann PV.

T-cell epitope mapping using the ELISPOT approach.
Methods. 2003, 29, 260-269.

Determinant Mapping/High-throughput Screening - Working with Peptides and Peptide Pools - Assay to Assay Reproducibility of Ex Vivo Measurements on PBMC - Infectious and Other Diseases -

Kreher CR, Dittrich MT, Guerkov R, Boehm BO, Tary-Lehmann M.

CD4+ and CD8+ cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assays.
Journal of Immunological Methods. 2003, 278, 79-93.

Working with Peptides and Peptide Pools - Assay to Assay Reproducibility of Ex Vivo Measurements on PBMC - Fresh versus Cryopreserved PBMC -

Li R, Liu T, Yoshihiro F, Tary-Lehmann M, Obrenovich M, Kuekrek H, Kang SC, Pan T, Wong BS, Medof ME, Sy MS.

On the same cell type GPI- anchored normal cellular prion and DAF protein exhibit different biological properties.
Biochemical and Biophysical Research Communications. 2003, 303, 446-451

Infectious and Other Diseases -

Hofstetter HH, Sewell DL, Liu F, Sandor M, Forsthuber T, Lehmann PV, Fabry Z.

Autoreactive T cells promote post-traumatic healing in the central nervous system.
Journal of Neuroimmunology. 2003, 134, 25-34.

Autoimmunity

Gebauer BS, Hricik DE, Atallah A, Bryan K, Riley J, Tary-Lehmann M, Greenspan NS, Dejelo C, Boehm BO, Hering BJ, Heeger PS.

Evolution of the enzyme-linked immunosorbent spot assay for post-transplant alloreactivity as a potentially useful immune monitoring tool.
American Journal of Transplantation. 2002, 2, 857.

Assay to Assay Reproducibility of Ex Vivo Measurements on PBMC - Fresh versus Cryopreserved PBMC - ELISPOT for Cells Other Than Human PBMC or Murine Lymph Node/Spleen Cells - Transplantation Immunology -

Meierhoff G, Ott PA, Lehmann PV, Schloot NC.

Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes.
Diabetes/Metabolism Research and Reviews. 2002, 18, 367-380.

Autoimmunity

Radeke HH, Tschernig T, Karulin AY, Schumm G, Emancipator SN, Resch K, Tary-Lehmann M.

CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury.
Clinical Immunology. 2002, 104, 161-173.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Autoimmunity

Stern BV, Boehm BO, Tary-Lehmann M.

Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity.
Journal of Immunology. 2002, 168, 6099-6105.

Working with Peptides and Peptide Pools - Vaccine and Adjuvants - Tumor Immunology -

Schlingmann TR, Rininsland FH, Bartholomae W, Boehm BO, Lehmann PV, Tary-Lehmann M.

Vaccination with tumor cells pulsed with foreign peptide induces immunity to the tumor itself.
Clinical Immunology. 2009, 133, 45-51.

Tumor Immunology -

Anthony DD, Valdez H, Post AB, Carlson NL, Heeger PS, Lehmann PV.

Comprehensive determinant mapping of the hepatitis C-specific CD8 cell repertoire reveals unpredicted immune hierarchy.
Clinical Immunology. 2002, 103, 264-276.

Determinant Mapping/High-throughput Screening - Infectious and Other Diseases -

Valdez, H., Carlson NL, Post AB, Asaad R, Heeger PS, Lederman MM, Lehmann PV, Anthony DD.

HIV long-term non-progressors maintain brisk CD8 T cell responses to other viral antigens.
AIDS. 2002, 16, 1113-1118.

Infectious and Other Diseases -

Karulin AY, Hesse MD, Yip HC, Lehmann PV.

Indirect IL-4 pathway in type 1 immunity.
Journal of Immunology. 2002, 168, 545-553.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Cognate Cytokine Production by T Cells versus Bystander Cytokine Production - Cytokine Coexpression/Two-color ELISPOT Assays -

Aung H, Sherman J, Tary-Lehmann M and Toossi Z.

Production of transforming growth factor-beta 1 (TGF-β1) expression in human monocytes infected with Mycobacterium avium at a single cell level by ELISPOT assay.
Journal of Immunological Methods. 2002, 259, 25-32.

ELISPOT for Cells Other Than Human PBMC or Murine Lymph Node/Spleen Cells - Infectious and Other Diseases -

Gottwein JM, Blanchard TG, Targoni OS, Eisenberg JC, Zagorski BM, Redline RW, Nedrud JG, Tary-Lehmann M, Lehmann PV, Czinn SJ.

Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund’s adjuvant by systemic immunization.
Journal of Infectious Diseases. 2001, 184, 308-314.

Vaccine and Adjuvants - Infectious and Other Diseases -

Baron ED, Heeger PS, Hricik DE, Schulak JA, Tary-Lehmann M, Stevens SR.

Immunomodulatory effect of extracorporeal photopheresis after successful treatment of resistant renal allograft rejection.
Photodermatology, Photoimmunology & Photomedicine. 2001, 17, 79-82.

Transplantation Immunology -

Hesse MD, Karulin AY, Boehm BO, Lehmann PV, Tary-Lehmann M.

A T cell clone's avidity is a function of its activation state.
Journal of Immunology. 2001, 167, 1353-1361

Single-cell Resolution and Frequency - Measurements of Functional T Cell Avidity - Spot Size Distribution - Working with Peptides and Peptide Pools -

Schwander SK, Torres M, Carranza CC, Escobedo D, Tary-Lehmann M, Anderson P, Toossi Z, Ellner JJ, Rich EA, Sada E.

Pulmonary mononuclear cell responses to antigens of Mycobacterium tuberculosis in healthy household contacts of patients with active tuberculosis and healthy controls from the community.
Journal of Immunology. 2000, 165, 1479-1485.

ELISPOT for Cells Other Than Human PBMC or Murine Lymph Node/Spleen Cells - Infectious and Other Diseases -

Rininsland FH, Helms T, Asaad RJ, Boehm BO, Tary-Lehmann M.

Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity.
Journal of Immunological Methods. 2000, 240, 143-155.

Cytotoxicity, Granzyme B, and Perforin ELISPOT - Infectious and Other Diseases -

Heeger PS, Valujskikh A, Lehmann PV.

Comprehensive assessment of determinant specificity, frequency, and cytokine signature of the primed CD8 cell repertoire induced by a minor transplantation antigen.
Journal of Immunology. 2000, 165, 12781284.

Determinant Mapping/High-throughput Screening - Working with Peptides and Peptide Pools - Transplantation Immunology -

Pelfrey CM, Rudick RA, Cotleur AC, Lee JC, Tary-Lehmann M, Lehmann PV.

Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production.
Journal of Immunology. 2000, 165, 1641-1651.

Working with Peptides and Peptide Pools - Autoimmunity

Heeger PS, Forsthuber TG, Shive C, Biekert E, Genain C, Hofstetter HH, Karulin AY, Lehmann PV.

Revisiting tolerance induced by autoantigen in incomplete Freund’s adjuvant.
Journal of Immunology. 2000, 164, 5771-5781.

Cytokine Coexpression/Two-color ELISPOT Assays - Vaccine and Adjuvants - AutoimmunityTransplantation Immunology -

Targoni OS, Baus J, Hofstetter HH, Hesse MD, Karulin AY, Boehm BO, Forsthuber TG, Lehmann PV.

Frequencies of neuroantigen-specific T cells in the central nervous system versus the immune periphery during the course of experimental allergic encephalomyelitis.
Journal of Immunology. 2001, 166, 4757-4764.

Autoimmunity Single-cell Resolution and Frequency -

Helms T, Boehm BO, Asaad RJ, Trezza RP, Lehmann PV, Tary-Lehmann M.

Direct visualization of cytokine-producing recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients.
Journal of Immunology. 2000, 164, 3723-3732

Single-cell Resolution and Frequency - Measuring Th1, Th2, Th17, and Other Effector Lineages - Assay to Assay Reproducibility of Ex Vivo Measurements on PBMC - Infectious and Other Diseases -

Lehmann PV.

Selective peptidomimetic blockers of autoantigen presentation: a novel therapeutic approach to autoimmune disease.
Trends in Pharmacological Sciences. 2000, 21, 79-80.

Autoimmunity

Karulin AY, Hesse MD, Tary-Lehmann M, Lehmann PV.

Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity.
Journal of Immunology. 2000, 164, 1862-1872.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Cytokine Coexpression/Two-color ELISPOT Assays - Spot Size Distribution -

Heeger PS, Greenspan NS, Kuhlenschmidt S, Dejelo C, Hricik DE, Schulak JA, Tary-Lehmann M.

Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.
Journal of Immunology. 1999, 163, 2267-2285.

Transplantation Immunology -

Targoni OS, Tary-Lehmann M, Lehmann PV.

Prevention of murine EAE by oral hydrolytic enzyme treatment.
Journal of Autoimmunity. 1999, 12, 191-198.

Autoimmunity

Yip HC, Karulin AY, Tary-Lehmann M, Hesse MD, Radeke H, Heeger PS, Trezza RP, Heinzel FP, Forsthuber TG, Lehmann PV.

Adjuvant-guided type- 1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response.
Journal of Immunology. 1999, 162, 3942-3949.

Determinant Mapping/High-throughput Screening - Vaccine and Adjuvants - Measuring Th1, Th2, Th17, and Other Effector Lineages - Measurements of Functional T Cell Avidity -

Schwander, SK, Torres M, E. Sada, C. Carranza, E. Ramos, Tary-Lehmann M, R. S. Wallis, J. Sierra, and E. A. Rich.

Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis.
Journal of Infectious Diseases. 1998, 178, 1434-1445.

ELISPOT for Cells Other Than Human PBMC or Murine Lymph Node/Spleen Cells - Infectious and Other Diseases -

Birnbaum G, Kotilinek L, Miller SD, Raine CS, Gao YL, Lehmann PV, Gupta RS.

Heat shock proteins and experimental autoimmune encephalomyelitis. II: environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis.
Journal of Neuroimmunology. 1998, 90, 149-161.

Autoimmunity

Lehmann PV.

The fate of T cells in the brain: veni, vidi, vici and veni, mori.
American Journal of Pathology. 1998, 153, 677-680.

Autoimmunity

Lehmann PV, Targoni OS, Forsthuber TG.

Shifting T-cell activation thresholds in autoimmunity and determinant spreading.
Immunological Review. 1998, 164, 53-61.

Autoimmunity

Tary-Lehmann M, Hricik DE, Justice AC, Potter NS, Heeger PS.

Enzyme-linked immunosorbent assay spot detection of interferon-gamma and interleukin 5-producing cells as a predictive marker for renal allograft failure.
Transplantation. 1998, 66, 219.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Transplantation Immunology -

Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT.

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.
Science. 1998, 281, 703-706.

AutoimmunityInfectious and Other Diseases -

Targoni OS Lehmann PV.

Endogenous myelin basic protein inactivates the high avidity T cell repertoire.
Journal of Experimental Medicine. 1998, 187, 2055-2063.

Measurements of Functional T Cell Avidity - Determinant Mapping/High-throughput Screening - Working with Peptides and Peptide Pools - Autoimmunity

Matesic D, Lehmann PV, Heeger PS.

High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.
Transplantation. 1998, 65, 906-914.

Transplantation Immunology -

Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV.

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
Journal of Experimental Medicine. 1997, 186, 1623-1631.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Working with Peptides and Peptide Pools - Vaccine and Adjuvants -

Lehmann PV, D. Matesic, G. Benichou, and Heeger PS.

Induction of T helper 2 immunity to an immunodominant allopeptide.
Transplantation. 1997, 64, 292-296.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Transplantation Immunology -

Tian J, Lehmann PV, and D. L. Kaufman.

Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens.
Journal of Experimental Medicine. 1997, 186, 2039-2043.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Autoimmunity

Tian J, Clare-Salzler M, Herschenfeld A, Middleton B, Newman D, Mueller R, Arita S, Evans C, Atkinson MA, Mullen Y, Sarvetnick N, Tobin AJ, Lehmann PV, Kaufman DL.

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nature Medicine. 1996, 2, 1348-1353.

Autoimmunity

Lehmann PV.

Immunomodulation by proteolytic enzymes
Nephrology Dialysis Transplantation. 1996, 11, 952-955.

Transplantation Immunology -

Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL.

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
Journal of Experimental Medicine. 1996, 183, 1561-1567

Autoimmunity

Forsthuber T, Yip HC, Lehmann PV.

Induction of TH1 and TH2 immunity in neonatal mice.
Science. 1996, 271, 1728-1730.

Measuring Th1, Th2, Th17, and Other Effector Lineages - Working with Peptides and Peptide Pools - Vaccine and Adjuvants -

Tary-Lehmann M., Saxon A, Lehmann PV.

The human immune system in hu-PBL-SCID mice.
Immunology Today. 1995, 16, 529-533.

Transplantation Immunology -

Tian J, Lehmann PV, Kaufman DL.

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.
Journal of Experimental Medicine. 1994, 180, 1979-1984.

Autoimmunity

Tary-Lehmann M, Lehmann PV, Schols D, Roncarolo MG, Saxon A.

Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras.
Journal of Experimental Medicine. 1994, 180,1817-1827.

Transplantation Immunology -

Benichou G., Fedoseyeva E, Lehmann PV, Olson CA, Geysen HM, McMillan M, Sercarz EE.

Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation.
Journal of Immunology. 1994, 153, 938-945.

Transplantation Immunology -

Uittenbogaart CH, Anisman DJ, Tary-Lehmann M, Vollger LW, Breit TM, Van Dongen JJ, Saxon A.

The SCID mouse environment causes immunophenotypic changes in human immature T-cell lines.
International Journal of Cancer. 1994, 56, 546-551.

Tumor Immunology -

Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV.

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Nature. 1993, 366, 69-72.

Autoimmunity

Sercarz EE, Lehmann PV, Ametani A, Benichou G, Miller A, Moudgil K.

Dominance and crypticity of T cell antigenic determinants.
Annual Review of Immunology. 1993, 11, 729-766.

Autoimmunity

Lehmann PV, Sercarz EE, Forsthuber T, Dayan CM, Gammon G.

Determinant spreading and the dynamics of the autoimmune T-cell repertoire.
Immunology Today. 1993, 14, 203-208.

Autoimmunity

Tary-Lehmann M., A. Saxon.

Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood.
Journal of Experimental Medicine. 1992, 175, 503-516.

Transplantation Immunology -

A. Saxon. , E Macy, K Denis, M Tary-Lehmann, O Witte, J Braun

Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans.
The Journal of Clinical Investigation. 1991, 87, 658-665.

Transplantation Immunology -

Lehmann PV, K. Drexler, Tary-Lehmann M, F. Falcioni, U. Hurtenbach, and Nagy ZA.

Graft-versus-host resistance induced by class II major histocompatibility complex-specific T cell clones.
Journal of Experimental Medicine. 1991, 173, 333-341.

Transplantation Immunology -

Tary-Lehmann, M., A. G. Rolink, Lehmann PV, Nagy ZA, and U. Hurtenbach

Induction of graft versus host-associated immunodeficiency by CD4+ T cell clones.
Journal of Immunology. 1990, 145, 2092-2098.

Transplantation Immunology

Przybyła A., Zhang T., Li R., Roen D.R., Mackiewicz A., and P. V. Lehmann (2018)

Natural T cell autoreactivity to melanoma antigens: clonally expanded melanoma-antigen specific CD8 + memory T cells can be detected in healthy humans.
Cancer Immunol. Immunotherapy 2019

Lehmann PV, Forsthuber T, Miller A, Sercarz EE.

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen.
Nature. 1992, 358, 155.

Autoimmunity

Falcioni F, Dembic Z, Mulller S, Lehmann PV, Nagy ZA.

Flexibility of the T cell repertoire. Self tolerance causes a shift of T cell receptor gene usage in response to insulin.
Journal of Experimental Medicine. 1990, 171, 1665-1681.

Autoimmunity

Lehmann PV, G. Schumm, D. Moon, U. Hurtenbach, F. Falcioni, Mulller S, and Nagy ZA.

Acute lethal graft-versus-host reaction induced by major histocompatibility complex class II-reactive T helper cell clones.
Journal of Experimental Medicine. 1990, 171, 1485-1496.

Transplantation Immunology -

Lehmann PV, Cardinaux F, Appella E, Muller S, Falcioni F, Adorini L, Nagy ZA.

Inhibition of T cell response with peptides is influenced by both peptide-binding specificity of major histocompatibility complex molecules and susceptibility of T cells to blocking.
European Journal of Immunology. 1989, 19, 1071-1077.

Working with Peptides and Peptide Pools -

Nagy ZA, Lehmann PV, Falcioni F, Muller S, Adorini L.

Why peptides? Their possible role in the evolution of MHC-restricted T-cell recognition.
Immunology Today. 1989, 10, 132-138

Working with Peptides and Peptide Pools -

Adorini L, Mulller S, Cardinaux F, Lehmann PV, Falcioni F, Nagy ZA.

In vivo competition between self peptides and foreign antigens in T-cell activation.
Nature. 1988, 334, 623-625.

Working with Peptides and Peptide Pools -

Adorini L, Sette A, Buus S, Grey HM, Darsley M, Lehmann PV, Doria G, Nagy ZA, Appella E.

Interaction of an immunodominant epitope with Ia molecules in T-cell activation.
Proceedings of the National Academy of Sciences. 1988, 85, 5181-5185.

Working with Peptides and Peptide Pools

Diego VP, Luu BW, Hofmann M, Dinh LV, Almeida M, Powell JS, Rajalingam R, Peralta JM, Kumar S, Curran JE, Sauna ZE, Kellerman R, Park Y, Key NS, Escobar MA, Huynh H, Verhagen AM, Williams-Blangero S, Lehmann PV, Maraskovsky E, Blangero J, Howard TE.

Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A.
J Thromb Haemost 2020,18, 201-216.

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